Article
The blood and vascular cell compatibility of heparin-modified ePTFE vascular grafts.
Biomaterials - 1 Jan 2013
Hoshi Ryan A, Van Lith Robert, Jen Michele C, Allen Josephine B, Lapidos Karen A, Ameer Guillermo
Abstract excerpt
Prosthetic vascular grafts do not mimic the antithrombogenic properties of native blood vessels and therefore have higher rates of complications that involve thrombosis and restenosis. We developed an approach for grafting bioactive heparin, a potent anticoagulant glycosaminoglycan, to the lumen of ePTFE vascular grafts to improve their interactions with blood and vascular cells. Heparin was bound to aminated...
Topics
- Adult
- Biocompatible Materials
- Blood Platelets
- Blood Vessel Prosthesis
- Cell Adhesion
- Cell Proliferation
- Cell Survival
- Cells, Cultured
- Citrates
- Coated Materials, Biocompatible
- Heparin
- Human Umbilical Vein Endothelial Cells
- Humans