Article
Characterization of a nuclear pore protein sheds light on the roles and composition of the Toxoplasma gondii nuclear pore complex.
Cellular and molecular life sciences : CMLS - 1 Jun 2017
Courjol Flavie, Mouveaux Thomas, Lesage Kevin, Saliou Jean-Michel, Werkmeister Elisabeth, Bonabaud Maurine, Rohmer Marine, Slomianny Christian, Lafont Franck, Gissot Mathieu
Abstract excerpt
The nuclear pore is a key structure in eukaryotes regulating nuclear-cytoplasmic transport as well as a wide range of cellular processes. Here, we report the characterization of the first Toxoplasma gondii nuclear pore protein, named TgNup302, which appears to be the orthologue of the mammalian Nup98-96 protein. We produced a conditional knock-down mutant that expresses TgNup302 under the control of an inducible...
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