Article
Restoration of dysgenic muscle contraction and calcium channel function by co-culture with normal spinal cord neurons.
Nature - 1 Jan 2000
Rieger F, Bournaud R, Shimahara T, Garcia L, Pinçon-Raymond M, Romey G, Lazdunski M
Abstract excerpt
Muscular dysgenesis (mdg) is a spontaneous recessive lethal mutation in the mouse. The disease is characterized by a total lack of excitation-contraction coupling in embryonic skeletal muscle. This developmental abnormality is associated with a drastic deficiency in the expression of voltage-sensitive Ca2+ channels in skeletal muscle without alteration of the properties of voltage-sensitive Na+ channels or of...
Topics
- Animals
- Cell Communication
- Cells, Cultured
- Evoked Potentials
- Genes, Lethal
- Genes, Recessive
- Ion Channels
- Mice
- Mice, Mutant Strains
- Muscle Contraction
- Muscles