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Article

The linker histone H1C contributes to the SCA7 nuclear phenotype.

Nucleus (Austin, Tex.) - 1 Jan 2000

Kizilyaprak Caroline, Spehner Danièle, Devys Didier, Schultz Patrick

Abstract excerpt

Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disease caused by a polyglutamine expansion in ataxin-7, a subunit of the SAGA coactivator, which leads to progressive neuronal dysfunction and cell death in cerebellum, brainstem and retina. Increased nuclear volume, chromatin decondensation and deregulated gene expression were reported in a SCA7 mouse model expressing mutant ataxin-7 in rod...

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Identifiers

PMID: 21970987
DOI: 10.4161/nucl.2.5.17843

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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