Article
TNF-α -308 G>A polymorphism and weight gain in patients with schizophrenia under long-term clozapine, risperidone or olanzapine treatment.
Neuroscience letters - 31 Oct 2011
Huang Hsiang-Hsuan, Wang Ying-Chieh, Wu Chia-Liang, Hong Chen-Jee, Bai Ya-Mei, Tsai Shih-Jen, Liou Ying-Jay
Abstract excerpt
Atypical or second-generation antipsychotics (SGAs) are associated with excessive body weight gain (BWG) and other components of metabolic syndrome. Among all SGAs, clozapine and olanzapine are known to cause the most significant weight gain, followed by risperidone and quetiapine. The genetic variant of tumor necrosis factor α (TNF-α), -308 G>A polymorphism (rs1800629), has been implicated in clozapine-induced...
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