Article
Dopamine receptor D2 gene is associated with weight gain in schizophrenic patients under long-term atypical antipsychotic treatment.
Pharmacogenetics and genomics - 1 Jun 2010
Hong Chen-Jee, Liou Ying-Jay, Bai Ya Mei, Chen Tzu-Ting, Wang Ying-Chieh, Tsai Shih-Jen
Abstract excerpt
OBJECTIVE: Schizophrenic patients treated with atypical antipsychotics (AAPs) often develop excessive body weight gain (BWG), which may lead to further morbidity and poor treatment compliance. This study examined whether genetic variants in the dopamine receptor D2 (DRD2) gene may be associated with body weight change after AAP treatment. METHODS: The study included 479 schizophrenic patients treated with...
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