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Article

Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population.

Journal of clinical psychopharmacology - 1 Jun 2007

Zhang Xiang Yang, Tan Yun Long, Zhou Dong Feng, Haile Colin N, Cao Lian Yuan, Xu Qi, Shen Yan, Kosten Therese A, Kosten Thomas R

Abstract excerpt

Weight gain is a problem commonly encountered with antipsychotic treatment and has become more apparent with increasing use of the newer atypical antipsychotics. The adipocyte-derived hormone, leptin, has been associated with body weight and energy homeostasis, and abnormal regulation of leptin could play a role in weight gain induced by antipsychotics. We investigated whether a leptin gene promoter variant...

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Source

Identifiers

PMID: 17502770
DOI: 10.1097/jcp.0b013e3180582412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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