Article
Single nucleotide polymorphism in hsa-mir-196a-2 and breast cancer risk: a case control study.
Twin research and human genetics : the official journal of the International Society for Twin Studies - 1 Oct 2011
Jedlinski Dominik J, Gabrovska Plamena N, Weinstein Stephen R, Smith Robert A, Griffiths Lyn R
Abstract excerpt
microRNAs are small, non-coding RNAs that influence gene expression on a post-transcriptional level. They participate in diverse biological pathways and may act as either tumor suppressor genes or oncogenes. As they may have an effect on thousands of target mRNAs, single-nucleotide polymorphisms in microRNA genes might have major functional consequences, because the microRNA's properties and/or maturation may...
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