Article
Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women.
Human mutation - 1 Jan 2009
Hu Zhibin, Liang Jie, Wang Zhanwei, Tian Tian, Zhou Xiaoyi, Chen Jiaping, Miao Ruifen, Wang Yan, Wang Xinru, Shen Hongbing
Abstract excerpt
Small, noncoding RNA molecules, called microRNAs (miRNAs), are thought to function as either tumor suppressors or oncogenes. Common single-nucleotide polymorphisms (SNPs) in miRNAs may change their property through altering miRNA expression and/or maturation, and thus they may have an effect on thousands of target mRNAs, resulting in diverse functional consequences. However, it remains largely unknown whether...
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