Article
Variation in BMPR1B, TGFRB1 and BMPR2 and control of dizygotic twinning.
Twin research and human genetics : the official journal of the International Society for Twin Studies - 1 Oct 2011
Luong Hien T T, Chaplin Justin, McRae Allan F, Medland Sarah E, Willemsen Gonneke, Nyholt Dale R, Henders Anjali K, Hoekstra Chantal, Duffy David L, Martin Nicholas G, Boomsma Dorret I, Montgomery Grant W, Painter Jodie N
Abstract excerpt
Genes in the TGF9 signaling pathway play important roles in the regulation of ovarian follicle growth and ovulation rate. Mutations in three genes in this pathway, growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15) and the bone morphogenetic protein receptor B 1 (BMPRB1), influence dizygotic (DZ) twinning rates in sheep. To date, only variants in GDF9 and BMP15, but not their receptors...
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