Article
Novel variants in growth differentiation factor 9 in mothers of dizygotic twins.
The Journal of clinical endocrinology and metabolism - 1 Nov 2006
Palmer James S, Zhao Zhen Zhen, Hoekstra Chantal, Hayward Nicholas K, Webb Penelope M, Whiteman David C, Martin Nicholas G, Boomsma Dorret I, Duffy David L, Montgomery Grant W
Abstract excerpt
CONTEXT: Genes from the ovarian bone morphogenetic signaling pathway (GDF9 and BMP15) are critical for normal human fertility. We previously identified a deletion mutation in GDF9 in sisters with spontaneous dizygotic (DZ) twins, but the prevalence of rare GDF9 variants in twinning families is unknown. OBJECTIVE: The objective was to evaluate the frequency of rare variants in GDF9 in families with a history of DZ...
Topics
- Bone Morphogenetic Protein 15
- Control Groups
- Female
- Gene Deletion
- Gene Frequency
- Genetic Testing
- Genetic Variation
- Growth Differentiation Factor 9
- Humans
- Intercellular Signaling Peptides and Proteins
- Mothers
- Pedigree