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Article

Variation in bone morphogenetic protein 15 is not associated with spontaneous human dizygotic twinning.

Human reproduction (Oxford, England) - 1 Oct 2008

Zhao Zhen Zhen, Painter Jodie N, Palmer James S, Webb Penelope M, Hayward Nicholas K, Whiteman David C, Boomsma Dorret I, Martin Nicholas G, Duffy David L, Montgomery Grant W

Abstract excerpt

BACKGROUND: Spontaneous dizygotic (DZ) twinning in humans is under genetic control. In sheep, heterozygous loss of function mutations in bone morphogenetic protein 15 (BMP15) increase ovulation and hence twinning rates. METHODS: To investigate the role of BMP15 in human twinning, we typed 14 common variants, 4 rare novel variants initially detected by sequencing 279 mothers of DZ twins (MODZT) and 17 variants...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18614612
DOI: 10.1093/humrep/den268
PMCID: PMC2721723

Genes

BMP15
GDF9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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