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Article

Functional heterogeneity of breast fibroblasts is defined by a prostaglandin secretory phenotype that promotes expansion of cancer-stem like cells.

PloS one - 1 Jan 2011

Rudnick Jenny A, Arendt Lisa M, Klebba Ina, Hinds John W, Iyer Vandana, Gupta Piyush B, Naber Stephen P, Kuperwasser Charlotte

Abstract excerpt

Fibroblasts are important in orchestrating various functions necessary for maintaining normal tissue homeostasis as well as promoting malignant tumor growth. Significant evidence indicates that fibroblasts are functionally heterogeneous with respect to their ability to promote tumor growth, but markers that can be used to distinguish growth promoting from growth suppressing fibroblasts remain ill-defined. Here we...

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Identifiers

PMID: 21957456
DOI: 10.1371/journal.pone.0024605
PMCID: PMC3177828

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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