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Article

Cellular organization and molecular differentiation model of breast cancer-associated fibroblasts

3 Apr 2017

Abstract excerpt

BACKGROUND: The role of cancer-associated fibroblasts (CAFs) during tumour progression is obscured by the inherently complex, heterotypic nature of fibroblast cells and behaviours in various subtypes of malignancies. Therefore, we sought to identify distinct fibroblast subpopulations at the single-cell level. METHODS: Using single-cell quantitative PCR as a powerful tool to study heterogeneity and rare cell...

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PMID: 28372546
DOI: 10.1186/s12943-017-0642-7

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