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Article

Autophagy Required for Hepatitis B Virus Replication in Transgenic Mice

29 Sept 2011

Abstract excerpt

Recent studies indicate that hepatitis B virus (HBV) may induce autophagy to enhance its replication in cell cultures. To understand whether autophagy can indeed enhance HBV replication in vivo, we generated HBV transgenic mice with liver-specific knockout of the Atg5 gene, a gene critical for the initiation of autophagy. Immunoblot analyses confirmed the inhibition of autophagy in the livers of Atg5 knockout...

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PMID: 21957292
DOI: 10.1128/jvi.06064-11

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