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Article

Adenoviruses induce autophagy to promote virus replication and oncolysis.

Virology - 20 Jul 2011

Rodriguez-Rocha Humberto, Gomez-Gutierrez Jorge G, Garcia-Garcia Aracely, Rao Xiao-Mei, Chen Lan, McMasters Kelly M, Zhou Heshan Sam

Abstract excerpt

Adenoviruses with deletion of E1b have been used in clinical trials to treat cancers that are resistant to conventional therapies. The efficacy of viral replication within cancer cells determines the results of oncolytic therapy, which remains poorly understood and requires further improvement. In this report, we show that adenoviruses induce autophagy by increasing the conversion of LC3-I to LC3-II and the...

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Identifiers

PMID: 21575980
DOI: 10.1016/j.virol.2011.04.017
PMCID: PMC3113480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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