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Article

Eradication of H. pylori did not improve abnormal sonic hedgehog expression in the high risk group for gastric cancer.

Digestive diseases and sciences - 1 Mar 2012

Shiotani Akiko, Murao Takahisa, Uedo Noriya, Iishi Hiroyasu, Yamanaka Yoshiyuki, Kamada Tomoari, Kusunoki Hiroaki, Inoue Kazuhiko, Haruma Ken

Abstract excerpt

BACKGROUND: Sonic hedgehog (SHH) acts as a proliferation factor in both the normal mucosa and in malignant lesions. Helicobacter pylori-associated atrophic gastritis is characterized by loss of SHH. AIM: The purpose of this study was to investigate the effects of H. pylori eradication on SHH mRNA and methylation levels in the patients at high risk for gastric cancer comparing to those in the controls. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21953141
DOI: 10.1007/s10620-011-1916-3

Genes

SHH
BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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