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Effects of <i>Helicobacter pylori</i> Eradication on Methylation Status of <i>E-Cadherin</i> Gene in Noncancerous Stomach

15 May 2006

Abstract excerpt

PURPOSE: Promoter hypermethylation of E-cadherin plays an important role on gastric cancer development. Whereas E-cadherin methylation was frequently detected in the stomach of Helicobacter pylori-infected individuals, we tested whether eradication of H. pylori alters the methylation status of the noncancerous gastric epithelium. EXPERIMENTAL DESIGN: Endoscopic biopsies were taken from the antrum and corpus of H....

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PMID: 16707623
DOI: 10.1158/1078-0432.ccr-05-2442

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