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Article

Modeling the study of DNA damage responses in mice.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2015

Specks Julia, Nieto-Soler Maria, Lopez-Contreras Andres J, Fernandez-Capetillo Oscar

Abstract excerpt

Damaged DNA has a profound impact on mammalian health and overall survival. In addition to being the source of mutations that initiate cancer, the accumulation of toxic amounts of DNA damage can cause severe developmental diseases and accelerate aging. Therefore, understanding how cells respond to DNA damage has become one of the most intense areas of biomedical research in the recent years. However, whereas most...

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Identifiers

PMID: 25636482
DOI: 10.1007/978-1-4939-2297-0_21
PMCID: PMC4878652

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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