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Article

An ENU-induced mutation of Nrg1 causes dilated pupils and a reduction in muscarinic receptors in the sphincter pupillae.

PloS one - 1 Jan 2011

Chen Bing, Li Ke, Zhang Fenli, Zhai Guoqin, Gong Wen, Qiang Sujing, Xue Zhengfeng

Abstract excerpt

BACKGROUND: N-ethyl-N-nitrosourea (ENU)-induced mutagenesis is a powerful tool for the study of gene function and the generation of human disease models. A large number of mouse mutants obtained by ENU-induced mutagenesis with a variety of phenotypes have been recovered. However, after genetic confirmation testing, only approximately 50% of the abnormal phenotypes were found to be heritable. METHODOLOGY/PRINCIPAL...

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Identifiers

PMID: 21949880
DOI: 10.1371/journal.pone.0025176
PMCID: PMC3176322

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Source receipt: pubmed, retrieved 7 Sept 2026.

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