Article
A monogenic dominant mutation in Rom1 generated by N-ethyl-N-nitrosourea mutagenesis causes retinal degeneration in mice.
Molecular vision - 10 Mar 2010
Sato Hajime, Suzuki Tomohiro, Ikeda Kyoko, Masuya Hiroshi, Sezutsu Hideki, Kaneda Hideki, Kobayashi Kimio, Miura Ikuo, Kurihara Yasuyuki, Yokokura Shunji, Nishida Kohji, Tamai Makoto, Gondo Yoichi, Noda Tetsuo, Wakana Shigeharu
Abstract excerpt
PURPOSE: To characterize an N-ethyl-N-nitrosourea-induced dominant mouse mutant, M-1156, that exhibits progressive retinal degeneration and to investigate the pathogenesis of the retinal phenotype in the mutant. METHODS: A positional candidate gene approach was used to identify the causative gene in the M-1156 mutant. Funduscopic examination, light microscopy, transmission electron microscopy, and...
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