Article
DRhoGEF2 regulates cellular tension and cell pulsations in the Amnioserosa during Drosophila dorsal closure.
PloS one - 1 Jan 2011
Azevedo Dulce, Antunes Marco, Prag Soren, Ma Xiaoyan, Hacker Udo, Brodland G Wayne, Hutson M Shane, Solon Jerome, Jacinto Antonio
Abstract excerpt
Coordination of apical constriction in epithelial sheets is a fundamental process during embryogenesis. Here, we show that DRhoGEF2 is a key regulator of apical pulsation and constriction of amnioserosal cells during Drosophila dorsal closure. Amnioserosal cells mutant for DRhoGEF2 exhibit a consistent decrease in amnioserosa pulsations whereas overexpression of DRhoGEF2 in this tissue leads to an increase in the...
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