Article
Identification of the bacterial protein FtsX as a unique target of chemokine-mediated antimicrobial activity against Bacillus anthracis.
Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 2011
Crawford Matthew A, Lowe David E, Fisher Debra J, Stibitz Scott, Plaut Roger D, Beaber John W, Zemansky Jason, Mehrad Borna, Glomski Ian J, Strieter Robert M, Hughes Molly A
Abstract excerpt
Chemokines are a family of chemotactic cytokines that function in host defense by orchestrating cellular movement during infection. In addition to this function, many chemokines have also been found to mediate the direct killing of a range of pathogenic microorganisms through an as-yet-undefined mechanism. As an understanding of the molecular mechanism and microbial targets of chemokine-mediated antimicrobial...
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