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Article

Edema Toxin Impairs Anthracidal Phospholipase A2 Expression by Alveolar Macrophages

3 Dec 2007

Abstract excerpt

Bacillus anthracis, the etiological agent of anthrax, is a spore-forming gram-positive bacterium. Infection with this pathogen results in multisystem dysfunction and death. The pathogenicity of B. anthracis is due to the production of virulence factors, including edema toxin (ET). Recently, we established the protective role of type-IIA secreted phospholipase A2 (sPLA2-IIA) against B. anthracis. A component of...

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PMID: 18069891
DOI: 10.1371/journal.ppat.0030187

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