Article
A microRNA-135a/b binding polymorphism in CD133 confers decreased risk and favorable prognosis of lung cancer in Chinese by reducing CD133 expression.
Carcinogenesis - 1 Oct 2013
Cheng Mei, Yang Lei, Yang Rongrong, Yang Xiaorong, Deng Jieqiong, Yu Bolan, Huang Dongsheng, Zhang Shuxu, Wang Hui, Qiu Fuman, Zhou Yifeng, Lu Jiachun
Abstract excerpt
CD133 is a pivotal marker of cancer stem cells (CSCs), which is involved in tumorigenesis and cancer progression. Recent studies have identified CD133 to be a prognostic factor for cancer rested with its expression and genetic variants. Here, we hypothesized that the single nuclear polymorphisms (SNPs) in CD133 may be associated with lung cancer risk and prognosis. Based on three independent case-control analyses...
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