Article
Elevated risk of hypertension induced by arsenic exposure in Taiwanese rural residents: possible effects of manganese superoxide dismutase (MnSOD) and 8-oxoguanine DNA glycosylase (OGG1) genes.
Archives of toxicology - 1 Jun 2012
Chen Shiuan-Chih, Chen Chun-Chieh, Kuo Chung-Yih, Huang Chun-Huang, Lin Chin-Hsiu, Lu Zi-Yun, Chen Yi-Yu, Lee Hong-Shen, Wong Ruey-Hong
Abstract excerpt
Heavy metals, including arsenic and lead, may lead to cellular oxidative damage that is linked to hypertension. Manganese superoxide dismutase (MnSOD) is a scavenger of reactive oxygen species, and 8-oxoguanine DNA glycosylase (OGG1) is the major glycosylase that repairs DNA lesions. Interestingly, whether there is an elevated risk of hypertension with arsenic or lead exposure in individuals with genetic...
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