Article
No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease.
Neurobiology of aging - 1 Apr 2012
Hillmann Antje, Hahn Stefanie, Schilling Stephan, Hoffmann Torsten, Demuth Hans-Ulrich, Bulic Bruno, Schneider-Axmann Thomas, Bayer Thomas A, Weggen Sascha, Wirths Oliver
Abstract excerpt
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that has been reported to reduce the risk of developing Alzheimer's disease (AD). Its preventive effects in AD are likely pleiotropic as ibuprofen displays both anti-inflammatory activity by inhibition of cyclooxygenases and anti-amyloidogenic activity by modulation of γ-secretase. In order to study the anti-inflammatory properties of ibuprofen...
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