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Article

Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice.

Brain research - 1 May 2008

McKee Ann C, Carreras Isabel, Hossain Lokman, Ryu Hoon, Klein William L, Oddo Salvatore, LaFerla Frank M, Jenkins Bruce G, Kowall Neil W, Dedeoglu Alpaslan

Abstract excerpt

We examined the effects of ibuprofen on cognitive deficits, Abeta and tau accumulation in young triple transgenic (3xTg-AD) mice. 3xTg-AD mice were fed ibuprofen-supplemented chow between 1 and 6 months. Untreated 3xTg-AD mice showed significant impairment in the ability to learn the Morris water maze (MWM) task compared to age-matched wild-type (WT) mice. The performance of 3xTg-AD mice was significantly...

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Identifiers

PMID: 18374906
DOI: 10.1016/j.brainres.2008.01.095
PMCID: PMC2587244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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