Prevention of siderophore- mediated gut-derived sepsis due to P. aeruginosacan be achieved without iron provision by maintaining local phosphate abundance: role of pH

Abstract excerpt

BACKGROUND: During extreme physiological stress, the intestinal tract can be transformed into a harsh environment characterized by regio- spatial alterations in oxygen, pH, and phosphate concentration. When the human intestine is exposed to extreme medical interventions, the normal flora becomes replaced by pathogenic species whose virulence can be triggered by various physico-chemical cues leading to lethal...

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