Article
Candida albicans isolates from the gut of critically ill patients respond to phosphate limitation by expressing filaments and a lethal phenotype.
PloS one - 1 Jan 2012
Romanowski Kathleen, Zaborin Alexander, Valuckaite Vesta, Rolfes Ronda J, Babrowski Trissa, Bethel Cindy, Olivas Andrea, Zaborina Olga, Alverdy John C
Abstract excerpt
Candida albicans is an opportunistic pathogen that proliferates in the intestinal tract of critically ill patients where it continues to be a major cause of infectious-related mortality. The precise cues that shift intestinal C. albicans from its ubiquitous indolent colonizing yeast form to an invasive and lethal filamentous form remain unknown. We have previously shown that severe phosphate depletion develops in...
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