Article
The C. elegans CHP1 homolog, pbo-1, functions in innate immunity by regulating the pH of the intestinal lumen.
PLoS pathogens - 1 Jan 2020
Benomar Saida, Lansdon Patrick, Bender Aaron M, Peterson Blake R, Chandler Josephine R, Ackley Brian D
Abstract excerpt
Caenorhabditis elegans are soil-dwelling nematodes and models for understanding innate immunity and infection. Previously, we developed a novel fluorescent dye (KR35) that accumulates in the intestine of C. elegans and reports a dynamic wave in intestinal pH associated with the defecation motor program. Here, we use KR35 to show that mutations in the Ca2+-binding protein, PBO-1, abrogate the pH wave, causing the...
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