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Article

Joint effects of alcohol consumption and polymorphisms in alcohol and oxidative stress metabolism genes on risk of head and neck cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2011

Hakenewerth Anne M, Millikan Robert C, Rusyn Ivan, Herring Amy H, North Kari E, Barnholtz-Sloan Jill S, Funkhouser William F, Weissler Mark C, Olshan Andrew F

Abstract excerpt

BACKGROUND: Single-nucleotide polymorphisms (SNP) in alcohol metabolism genes are associated with squamous cell carcinoma of the head and neck (SCCHN) and may influence cancer risk in conjunction with alcohol. Genetic variation in the oxidative stress pathway may impact the carcinogenic effect of reactive oxygen species produced by ethanol metabolism. We hypothesized that alcohol interacts with these pathways to...

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Source

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Identifiers

PMID: 21940907
DOI: 10.1158/1055-9965.EPI-11-0649
PMCID: PMC3210881

Genes

ALDH2
SOD2
ADH7
GPX2
IMPACT
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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