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Article

Effects of polymorphisms in alcohol metabolism and oxidative stress genes on survival from head and neck cancer.

Cancer epidemiology - 1 Aug 2013

Hakenewerth Anne M, Millikan Robert C, Rusyn Ivan, Herring Amy H, Weissler Mark C, Funkhouser William K, North Kari E, Barnholtz-Sloan Jill S, Olshan Andrew F

Abstract excerpt

BACKGROUND: Heavy alcohol consumption increases risk of developing squamous cell carcinoma of the head and neck (SCCHN). Alcohol metabolism to cytotoxic and mutagenic intermediates acetaldehyde and reactive oxygen species is critical for alcohol-drinking-associated carcinogenesis. We hypothesized that polymorphisms in alcohol metabolism-related and antioxidant genes influence SCCHN survival. METHODS: Interview...

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Source

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Identifiers

PMID: 23632049
DOI: 10.1016/j.canep.2013.03.010
PMCID: PMC3725265

Genes

ADH4
ADH7
ALDH2
CAT
SOD1
SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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