Article
Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human large bowel: association of the functional polymorphisms of ADH and ALDH genes with hemorrhoids and colorectal cancer.
Alcohol (Fayetteville, N.Y.) - 1 Feb 2012
Chiang Chien-Ping, Jao Shu-Wen, Lee Shiao-Pieng, Chen Pei-Chi, Chung Chia-Chi, Lee Shou-Lun, Nieh Shin, Yin Shih-Jiun
Abstract excerpt
Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are principal enzymes responsible for metabolism of ethanol. Functional polymorphisms of ADH1B, ADH1C, and ALDH2 genes occur among racial populations. The goal of this study was to systematically determine the functional expressions and cellular localization of ADHs and ALDHs in human rectal mucosa, the lesions of adenocarcinoma and hemorrhoid, and the...
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