Article
Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human pancreas: implications for pathogenesis of alcohol-induced pancreatic injury.
Alcoholism, clinical and experimental research - 1 Jun 2009
Chiang Chien-Ping, Wu Chew-Wun, Lee Shiao-Pieng, Chung Chia-Chi, Wang Chi-Wei, Lee Shou-Lun, Nieh Shin, Yin Shih-Jiun
Abstract excerpt
BACKGROUND: Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are major enzymes responsible for metabolism of ethanol. Genetic polymorphisms of ADH1B, ADH1C, and ALDH2 occur among racial populations. The metabolic effect and metabolites contribute to pathogenesis of pancreatic injury. The goal of this study was to determine the functional expressions and cellular localization of ADH and ALDH families...
Topics
- Adult
- Aged
- Alcohol Dehydrogenase
- Aldehyde Dehydrogenase
- Aldehyde Dehydrogenase, Mitochondrial
- Central Nervous System Depressants
- Ethanol
- Female
- Gene Expression Regulation
- Genotype
- Hepatic Stellate Cells
- Humans