Article
Differential roles of TLR2 and TLR4 in the host response to Gram-negative bacteria: lessons from a lipopolysaccharide-deficient mutant of Neisseria meningitidis.
Journal of endotoxin research - 1 Jan 2000
Ingalls R R, Lien E, Golenbock D T
Abstract excerpt
The inflammatory response to bacterial infections plays an important role in the detection and elimination of invading micro-organisms. Various components of the bacterial cell wall are capable of activating this pro-inflammatory response. In the case of Gram-negative bacteria, lipopolysaccharide (LPS) is the dominant trigger, although other bacterial factors are also capable of activating this systemic...
Topics
- Animals
- CHO Cells
- Cell Wall
- Cricetinae
- Drosophila Proteins
- Humans
- In Vitro Techniques
- Inflammation Mediators
- Leukocytes, Mononuclear
- Lipopolysaccharide Receptors
- Lipopolysaccharides