Article
A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection.
Infection and immunity - 1 Oct 2003
Jerse Ann E, Sharma Nirmala D, Simms Amy N, Crow Emily T, Snyder Lori A, Shafer William M
Abstract excerpt
Active efflux of antimicrobial substances is likely to be an important bacterial defense against inhibitory host factors inherent to different body sites. Two well-characterized multidrug resistance efflux systems (MtrCDE and FarAB-MtrE) exist in Neisseria gonorrhoeae, a bacterial pathogen of the human genital mucosae. In vitro studies suggest that the MtrCDE and FarAB-MtrE efflux systems protect the gonococcus...
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