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Article

An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5.

RNA (New York, N.Y.) - 1 Nov 2011

Ramachandran Sheetal, Tran Doan Duy Hai, Klebba-Faerber Sabine, Kardinal Christian, Whetton Anthony D, Tamura Teruko

Abstract excerpt

In response to DNA damage, transcription is blocked by inhibition of RNA polymerase II activity. The regulation of a preexisting pool of mRNAs, therefore, plays a key role in DNA repair, cell cycle arrest, or inhibition of differentiation. THOC5 is a member of the THO complex and plays a role in the export of a subset of mRNA, which plays an important role in hematopoiesis and maintaining primitive cells. Since...

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Identifiers

PMID: 21937706
DOI: 10.1261/rna.2820911
PMCID: PMC3198589

Genes

THOC5
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5.PMID 21937706Read ↗

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