Identification of Wnt Pathway Target Genes Regulating the Division and Differentiation of Larval Seam Cells and Vulval Precursor Cells in Caenorhabditis elegans.

doi:10.1534/g3.115.017715

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Article

Identification of Wnt Pathway Target Genes Regulating the Division and Differentiation of Larval Seam Cells and Vulval Precursor Cells in Caenorhabditis elegans.

G3 (Bethesda, Md.) - 5 Jun 2015

Gorrepati Lakshmi, Krause Michael W, Chen Weiping, Brodigan Thomas M, Correa-Mendez Margarita, Eisenmann David M

Abstract excerpt

The evolutionarily conserved Wnt/β-catenin signaling pathway plays a fundamental role during metazoan development, regulating numerous processes including cell fate specification, cell migration, and stem cell renewal. Wnt ligand binding leads to stabilization of the transcriptional effector β-catenin and upregulation of target gene expression to mediate a cellular response. During larval development of the...

Topics

Alleles
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Casein Kinase II
Cell Differentiation
Cyclin-Dependent Kinase Inhibitor Proteins
Female
Genes, Reporter
Larva

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Array Sequence Analysis

RNA Interference

RNA, Messenger

Temperature

Transcription Factors

Vulva

Wnt Proteins

Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 26048561
DOI: 10.1534/g3.115.017715
PMCID: PMC4528312

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26048561-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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