Article
Identification of Wnt Pathway Target Genes Regulating the Division and Differentiation of Larval Seam Cells and Vulval Precursor Cells in Caenorhabditis elegans.
G3 (Bethesda, Md.) - 5 Jun 2015
Gorrepati Lakshmi, Krause Michael W, Chen Weiping, Brodigan Thomas M, Correa-Mendez Margarita, Eisenmann David M
Abstract excerpt
The evolutionarily conserved Wnt/β-catenin signaling pathway plays a fundamental role during metazoan development, regulating numerous processes including cell fate specification, cell migration, and stem cell renewal. Wnt ligand binding leads to stabilization of the transcriptional effector β-catenin and upregulation of target gene expression to mediate a cellular response. During larval development of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.