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Article

Pre-fibrillar α-synuclein mutants cause Parkinson's disease-like non-motor symptoms in Drosophila.

PloS one - 1 Jan 2011

Gajula Balija Madhu Babu, Griesinger Christian, Herzig Alf, Zweckstetter Markus, Jäckle Herbert

Abstract excerpt

Parkinson's disease (PD) is linked to the formation of insoluble fibrillar aggregates of the presynaptic protein α-Synuclein (αS) in neurons. The appearance of such aggregates coincides with severe motor deficits in human patients. These deficits are often preceded by non-motor symptoms such as s...

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Identifiers

PMID: 21931820
DOI: 10.1371/journal.pone.0024701
PMCID: PMC3169624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21931820-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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