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Article

Genetic effects at pleiotropic loci are context-dependent with consequences for the maintenance of genetic variation in populations.

PLoS genetics - 1 Sept 2011

Lawson Heather A, Cady Janet E, Partridge Charlyn, Wolf Jason B, Semenkovich Clay F, Cheverud James M

Abstract excerpt

Context-dependent genetic effects, including genotype-by-environment and genotype-by-sex interactions, are a potential mechanism by which genetic variation of complex traits is maintained in populations. Pleiotropic genetic effects are also thought to play an important role in evolution, reflecting functional and developmental relationships among traits. We examine context-dependent genetic effects at pleiotropic...

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Identifiers

PMID: 21931559
DOI: 10.1371/journal.pgen.1002256
PMCID: PMC3169520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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