Risk of population extinction from fixation of deleterious and reverse mutations.

Abstract excerpt

A model is developed for alternate fixations of mildly deleterious and wild-type alleles arising by forward and reverse mutation in a finite population. For almost all parameter values, this gives an equilibrium load that agrees closely with the general expression derived from diffusion theory. Nearly neutral mutations with selection coefficient a few times larger than 1/(2N(e)) do the most damage by increasing...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genetic Variation
• Share to Models, Genetic
• Share to Models, Statistical