Limits to the rate of adaptive substitution in sexual populations.

doi:10.1371/journal.pgen.1002740

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Article

Limits to the rate of adaptive substitution in sexual populations.

PLoS genetics - 1 Jan 2012

Weissman Daniel B, Barton Nicholas H

Abstract excerpt

In large populations, many beneficial mutations may be simultaneously available and may compete with one another, slowing adaptation. By finding the probability of fixation of a favorable allele in a simple model of a haploid sexual population, we find limits to the rate of adaptive substitution,...

Topics

Adaptation, Biological
Alleles
Computer Simulation
Gene Frequency
Genetic Drift
Genetic Linkage
Models, Genetic
Mutation
Recombination, Genetic
Selection, Genetic

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