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Article

[Molecular mechanism and therapeutic strategy for cerebral small vessel disease].

Rinsho shinkeigaku = Clinical neurology - 1 Nov 2010

Hara Kenju

Abstract excerpt

Hypertension is a well known risk factor for cerebral small vessel disease (SVD) characterized by MRI white matter hyperintensities called "leukoaraiosis". However, the molecular basis of SVD remains to be elucidated. Both twin and family studies have shown that leukoaraiosis is the most heritable cerebrovascular phenotype with a heritability estimated to be between 55% and 71%, suggesting genetic factors for...

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Identifiers

PMID: 21921470
DOI: 10.5692/clinicalneurol.50.852

Genes

BMP2
BMP4
FBN1

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