Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease.

doi:10.1056/NEJMoa0801560

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Article

Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease.

The New England journal of medicine - 23 Apr 2009

Hara Kenju, Shiga Atsushi, Fukutake Toshio, Nozaki Hiroaki, Miyashita Akinori, Yokoseki Akio, Kawata Hirotoshi, Koyama Akihide, Arima Kunimasa, Takahashi Toshiaki, Ikeda Mari, Shiota Hiroshi, Tamura Masato, Shimoe Yutaka, Hirayama Mikio, Arisato Takayo, Yanagawa Sohei, Tanaka Akira, Nakano Imaharu, Ikeda Shu-ichi, Yoshida Yutaka, Yamamoto Tadashi, Ikeuchi Takeshi, Kuwano Ryozo, Nishizawa Masatoyo, Tsuji Shoji, Onodera Osamu

Abstract excerpt

BACKGROUND: The genetic cause of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL), which is characterized by ischemic, nonhypertensive, cerebral small-vessel disease with associated alopecia and spondylosis, is unclear. METHODS: In five families with CARASIL, we carried out linkage analysis, fine mapping of the region implicated in the disease, and sequence...

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Identifiers

PMID: 19387015
DOI: 10.1056/NEJMoa0801560

Genes

HTRA1

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Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease.PMID 19387015Read ↗

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