Article
The number of prognostically detrimental mutations and prognosis in primary myelofibrosis: an international study of 797 patients.
Leukemia - 1 Sept 2014
Guglielmelli P, Lasho T L, Rotunno G, Score J, Mannarelli C, Pancrazzi A, Biamonte F, Pardanani A, Zoi K, Reiter A, Duncombe A, Fanelli T, Pietra D, Rumi E, Finke C, Gangat N, Ketterling R P, Knudson R A, Hanson C A, Bosi A, Pereira A, Manfredini R, Cervantes F, Barosi G, Cazzola M, Cross N C P, Vannucchi A M, Tefferi A
Abstract excerpt
We recently defined a high-molecular risk category (HMR) in primary myelofibrosis (PMF), based on the presence of at least one of the five 'prognostically detrimental' mutated genes (ASXL1, EZH2, SRSF2 and IDH1/2). Herein, we evaluate the additional prognostic value of the 'number' of mutated genes. A total of 797 patients were recruited from Europe (n=537) and the Mayo Clinic (n=260). In the European cohort, 167...
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