Article
A conceptual framework for pharmacodynamic genome-wide association studies in pharmacogenomics.
Drug discovery today - 1 Oct 2011
Wu Rongling, Tong Chunfa, Wang Zhong, Mauger David, Tantisira Kelan, Szefler Stanley J, Chinchilli Vernon M, Israel Elliot
Abstract excerpt
Genome-wide association studies (GWAS) have emerged as a powerful tool to identify loci that affect drug response or susceptibility to adverse drug reactions. However, current GWAS based on a simple analysis of associations between genotype and phenotype ignores the biochemical reactions of drug response, thus limiting the scope of inference about its genetic architecture. To facilitate the inference of GWAS in...
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