Article
No association between mannose-binding lectin deficiency and H1N1 2009 infection observed during the first season of this novel pandemic influenza virus.
Human immunology - 1 Nov 2011
Eisen Damon P, Marshall Caroline, Dean Melinda M, Sasadeusz Joe, Richards Michael, Buising Kirsty, Cheng Allen, Johnson Paul D R, Barr Ian G, McBryde Emma S
Abstract excerpt
Genetic variations in host immunity may influence susceptibility to novel infections like the recently emergent pandemic influenza virus. Prior studies demonstrated that mannose-binding lectin (MBL) inactivates influenza. Furthermore, MBL deficiency is common and appears to predispose to respiratory virus infections. Therefore, we studied whether MBL deficiency played a role in infection with the novel H1N1 2009...
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