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Article

Quorum quenching quandary: resistance to antivirulence compounds.

The ISME journal - 1 Mar 2012

Maeda Toshinari, García-Contreras Rodolfo, Pu Mingming, Sheng Lili, Garcia Luis Rene, Tomás Maria, Wood Thomas K

Abstract excerpt

Quorum sensing (QS) is the regulation of gene expression in response to the concentration of small signal molecules, and its inactivation has been suggested to have great potential to attenuate microbial virulence. It is assumed that unlike antimicrobials, inhibition of QS should cause less Darwinian selection pressure for bacterial resistance. Using the opportunistic pathogen Pseudomonas aeruginosa, we...

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Identifiers

PMID: 21918575
DOI: 10.1038/ismej.2011.122
PMCID: PMC3280137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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