Article
Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens
13 Mar 2007
Abstract excerpt
Conventional antibiotics target the growth and the basal life processes of bacteria leading to growth arrest and cell death. The selective force that is inherently linked to this mode of action eventually selects out antibiotic-resistant variants. The most obvious alternative to antibiotic-mediated killing or growth inhibition would be to attenuate the bacteria with respect to pathogenicity. The realization that...
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